Cancer Types

Pancreatic Cancer

AGITG TROG 21D RESOLUTE

This study aims to assess the clinical benefit of local ablative therapy (LAT) following initial standard fist-line systemic treatment, compared to continued standard first-line systemic treatment in patients with unresectable...

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TROG 01.02 – PCNSL

This clinical research study looked at a new combination of chemotherapy drugs (Idarubicin and Methotrexate) followed by a lower dose of radiotherapy in participants with Primary Central Nervous System Lymphoma...

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TROG 03.04 – RADAR

Six months of hormone treatment improves the results of radiotherapy for men with early prostate cancer. This trial will determine if adding another 12 months of hormone treatment after radiotherapy...

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TROG 18.07

The Australian Particle Therapy Evidence Generating Network for Rare and Difficult-to-treat cancers

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TROG 03.01 – Oesophagus

People with cancer of the oesophagus (gullet) often have trouble swallowing. Radiotherapy can help improve this problem. Using chemotherapy together with radiotherapy may work better but has more side effects....

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ALLG/HDNLHL04/TROG 03.03

Treatment options for patients with relapsed lymphoma include standard-dose chemotherapy, radiotherapy or high-dose chemotherapy and peripheral blood stem cell transplantation. It has been found that if lymphoma recurs after transplantation...

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MA.20/NCIC CTG/TROG 03.05 – MA.20

Radiotherapy to the breast reduces the risk of cancer coming back for women with early breast cancer. This international study will determine if treating a larger area with radiotherapy can...

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TROG 05.01 – POST

For patients who have undergone surgery for high-risk skin cancer of the head and neck, this study aims to determine whether there is a difference in time to loco-regional relapse...

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TROG 05.02 – MALT Lymphoma

The main aim of this study is to test the effectiveness of radiotherapy for marginal zone lymphoma that has developed outside the stomach. The treatment that is given in the...

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TROG 06.02 – APBI

Breast cancer is a disease that can be treated with surgery to remove the part of the breast that has the cancer followed by radiation treatment to the whole breast....

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TROG 07.03 – RadioHUM

Radiotherapy for head and neck cancer may cause the lining of the mouth and throat to become inflamed and sore during treatment. This lining is called the oral mucosa and...

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TROG 07.04

The purpose of this study is to assess the safety and feasibility of combining radiotherapy and carboplatin (a chemotherapy drug) with a new drug called cetuximab in patients with locally...

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TROG 09.01 – PROArCT

Locally advanced rectal cancer is a cancer of the rectum that has a high risk of recurrence. In general, patients with this condition would benefit from further treatment in addition...

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TROG 09.02 – CHISEL

The purpose of this study is to investigate whether radiotherapy given as three large doses over a period of two weeks (hypofractionated radiotherapy) is more effective than standard radiotherapy for...

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TROG 11.02 – SCORAD III

Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which radiation therapy regimen is more effective in treating metastatic spinal cord compression. This randomised clinical...

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TROG 11.03 – PLUNG_GP/ALTG

The purpose of this study is to investigate whether adding chemotherapy to a short (less than six weeks) course of radiotherapy results in a greater improvement in symptoms and overall...

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TROG 14.04 – HART

TROG 14.04 tested the feasibility of Deep Inhalation Breath Hold (DIBH) to reduce heart radiation dose in left sided breast cancer patients in a multicentre setting. Patient reported outcomes such...

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TROG 15.01 – SPARK

Most linear accelerators used to treat cancer patients today are equipped with fixed X-ray imagers which are typically used to take images of a tumour before a patient receives radiotherapy....

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TROG 99.03 – Follicular Lymphoma

For patients with stage I and II low grade follicular lymphoma radiotherapy will cure 40-50% of cases. This study is comparing standard therapy (radiotherapy) and investigational therapy (radiotherapy plus chemotherapy)...

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UON/TROG 12.03 – EAT

This study is evaluating the effectiveness of a dietitian delivered health behaviour intervention to reduce malnutrition in head and neck cancer patients undergoing radiotherapy. You may be eligible to join...

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BIG 307/TROG 07.01 – DCIS

DCIS is the name for a condition in which abnormal cells are contained within the milk ducts of the breast. DCIS is not an invasive breast cancer however, if left...

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TROG 08.03 – RAVES

There are currently two ways of managing the treatment of men who have had a radical prostatectomy. The first option is to give radiotherapy immediately after surgery to everyone. Researchers...

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CKTO/TROG 08.04 – PORTEC-3

This study compares radiation plus chemotherapy with radiation alone in treating women with endometrial cancer that is classified as high risk or advanced stage. Participants will be divided into two...

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MASC 01.07/TROG 08.05 – WBRT

The purpose of this study is to investigate the effect of adding whole brain radiotherapy after surgery and/or stereotactic irradiation (SI) on the development of further brain metastases (cancer spread...

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TROG 08.06 – STARS

This study compares the effectiveness of treatment with the drug anastrozole before and during adjuvant radiotherapy compared with anastrozole therapy delayed until after radiotherapy. This study is for woman who...

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MASC 01.09/TROG 08.09 – RTN2

This trial is suitable for people that have been diagnosed with an unusual form of melanoma known as neurotropic melanoma. Neurotropic melanoma is characterised by the presence of melanoma cells...

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TROG 09.03 – MP3

This study aims to develop a well-tolerated chemo-radiotherapy treatment for patients with Merkel Cell Carcinoma (MCC) of the skin, which achieves high rates of cancer control. The researchers will be...

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BIG 2-04/MRC/TROG 11.01 – SUPREMO

This trial included patients that were diagnosed with breast cancer and had the cancer completely removed by surgery (mastectomy). Patients on the trial were given anti-cancer drugs in the form...

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TROG 12.02 – PET LABRADOR

Fit women with locally advanced breast cancer (LABC) are treated with a combination of chemotherapy, radiation treatment and surgery. There is no set order for the radiation treatment or surgery,...

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TROG 14.02 – RAIDER

Radiation treatment alone or in combination with chemotherapy can cure bladder cancer. The higher the radiation dose to the tumour the higher the chances of curing the cancer, however, higher...

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TROG 14.03 – EORTC 1219

The drug nimorazole belongs to a class of chemicals known as 5-nitroimidazoles. Drugs from this class are used against infection. In addition, nimorazole makes tumour cells more sensitive to radiotherapy....

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TROG 15.03 – FASTRACK II/ANZUP 16001

Surgery is the standard treatment for primary kidney cancer, however, in some cases surgery is either not possible or other health problems make surgery high risk. This study involves a...

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ALTG 14/002/CT0135/TROG 16.01 – NIVORAD

The aim of this study is to determine the activity and safety of treating an asymptomatic, extrapulmonary metastasis with a single fraction of SABR, during immunotherapy with nivolumab in advanced...

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ICR-CTSU/2015/15552/TROG 16.03 – CORE

CORE is a phase II/III, multicentre, non-blinded, randomised controlled trial in patients with breast, prostate or non-small cell lung cancer (NSCLC) primary cancer to evaluate if the addition of stereotactic...

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TROG 13.01 – SAFRON II/ALTG 13.001

Stereotactic body radiotherapy (SBRT) is a new form of cancer radiotherapy treatment and there are two SABR techniques emerging in Australia; single session and multi session. This study will examine...

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USYD/TROG 17.03 – LARK

This trial aims to show that incorporating Kilovoltage Intrafraction Monitoring (KIM) into liver SABR improves treatment accuracy, patient treatment outcomes and treatment efficiency.

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TROG 16.02 – LOCAL Her-O

For patients who have HER2 positive breast cancer which has spread to the brain (metastasised) the main treatment options for these brain metastases are as follows: Whole Brain Radiotherapy (WBRT),...

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ANZ 1601/BIG 16-02/TROG 16.04 – EXPERT

The current standard of care for patients with early breast cancer is radiation therapy (RT) after breast conserving surgery to improve cancer control. However, breast cancer is a complex disease,...

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AGITG/TROG 18.04 – MASTERPLAN

The aim of the trial is to assess the benefit of adding high precision radiation therapy to chemotherapy and surgery for the treatment of pancreatic cancer.

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TROG 17.02 – OUTRUN

20-40% of patients with NSCLC will develop brain metastases at some point during their course of the disease. Osimertinib has demonstrated intracranial activity in EFGR mutated NSCLC with leptomeningeal disease...

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AGITG AG0407GR/TROG 08.08 – TOPGEAR

The aim of this trial is to investigate whether pre-operative treatment with chemotherapy plus radiation therapy has a better outcome than chemotherapy alone in patients undergoing surgery for resectable gastric...

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PMC 17/013/TROG 17.05 – AZTEC

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression of oestrogen (ER) and progesterone (PR) receptors and lacks overexpression or amplification of the HER2/NEU gene....

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EORTC 13.08/TROG 15.02 – ROAM

Atypical meningioma is a tumour that arises from the lining of the brain. It mostly affects adults, with most patients in the 40-60 year age group. The primary treatment for...

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TROG 18.01 – NINJA

NINJA is comparing two emerging, potentially practice-changing radiotherapy schedules for Prostate Cancer, delivered in as little as 5 outpatient visits. Leveraging state-of-the-art technology we aim to use existing equipment throughout...

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