Open Trials - In Follow Up - TROG Cancer Research

BIG 307/TROG 07.01 – DCIS

A randomised phase III study of radiation doses and fractionation schedules in non-low risk ductal carcinoma in-situ (DCIS) of the breast

TROG 08.06 – STARS

A Randomised comparison of anastrozole commenced before and continuing during adjuvant radiotherapy for breast cancer versus anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy.

TROG 12.01 – HPV OROPHARYNX

A randomised trial of weekly cetuximab and radiation versus weekly cisplatin and radiation in good prognosis loco regionally advanced HPV-associated oropharyngeal squamous cell carcinoma

TROG 12.02 – PET LABRADOR

PET scans for locally advanced breast cancer and diagnostic MRI to determine the extent of operation and radiotherapy

TROG 15.03/ANZUP 16001 – FASTRACK II

Focal Ablative STereotactic RAdiosurgery for Cancers of the Kidney - a Phase II Clinical Trial

TROG 17.02 – OUTRUN

Randomised phase II trial of Osimertinib with or without stereotactic radiosurgery for EGFR mutated NSCLC with brain metastases

BIG 2-04/MRC/TROG 11.01 – SUPREMO

A phase III randomised trial to assess the role of adjuvant chest wall irradiation in 'intermediate risk' operable breast cancer following mastectomy. SUPREMO (Selective Use of Postoperative Radiotherapy after MastectOmy)

EORTC 13.08/TROG 15.02 – ROAM

Radiation versus Observation following surgical resection of Atypical Meningioma: a randomised controlled trial

EORTC 22033-26033/TROG 06.01 (Low Grade Glioma)

Primary chemotherapy with temozolomide vs. radiotherapy in patients with low grade gliomas after stratification for genetic 1p loss: a phase III study

ICR-CTSU/2015/15552/TROG 16.03 – CORE

A randomised trial of Conventional care versus Radioablation (stereotactic body radiotherapy) for Extracranial oligometastases

TROG 14.02 – RAIDER

A randomised phase II trial of adaptive image guided standard or dose escalated radiotherapy in the treatment of transitional cell carcinoma of the bladder

TROG 14.03 – EORTC 1219

A blind randomized multicentre study of accelerated fractionated chemo-radiotherapy with or without the hypoxic cell radiosensitizer nimorazole (Nimoral), using a 15-gene signature for hypoxia in the treatment of squamous cell carcinoma of the head and neck.

AGITG AG0407GR/TROG 08.08 – TOPGEAR

A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer.

CKTO/TROG 08.04 – PORTEC-3

Randomised phase III trial comparing concurrent chemoradiation and adjuvant chemotherapy with pelvic radiation alone in high risk and advanced stage endometrial carcinoma

TROG 14.01 – ENZARAD

Randomised phase 3 trial of radiation plus androgen deprivation therapy with or without enzalutamide for high risk, clinically localised, prostate cancer

PMC 17/013/TROG 17.05 – AZTEC

A randomised phase II trial comparing the efficacy of single fraction or multi-fraction SABR (stereotactic ablative body radiotherapy) with Atezolizumab in patients with advanced Triple-Negative Breast Cancer

Open Trials – In Follow Up