Open Trials – In Follow Up

TROG Cancer Research radiation therapy trials now recruiting, also known as current or open trials, are those that are fully approved and accepting participants. Our specialised radiation therapy trials are conducted by a team of dedicated professionals. To find out if you are eligible for a trial, please talk to your treating specialist in the first instance.

BIG 307/TROG 07.01 – DCIS

A randomised phase III study of radiation doses and fractionation schedules in non-low risk ductal carcinoma in-situ (DCIS) of the breast

TROG 08.03 – RAVES

A phase III multi-centre randomised trial comparing adjuvant radiotherapy (RT) with early salvage RT in patients with positive margins or extra prostatic disease following radical prostatectomy.

TROG 08.06 – STARS

A Randomised comparison of anastrozole commenced before and continuing during adjuvant radiotherapy for breast cancer versus anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy.

TROG 09.03 – MP3

A phase II efficacy study of chemo-radiotherapy in PET stage II and III Merkel cell carcinoma of the skin.


A randomised trial of weekly cetuximab and radiation versus weekly cisplatin and radiation in good prognosis loco regionally advanced HPV-associated oropharyngeal squamous cell carcinoma


Focal Ablative STereotactic RAdiosurgery for Cancers of the Kidney - a Phase II Clinical Trial

TROG 16.02 – LOCAL Her-O

A phase II study of local therapy only (stereotactic radiosurgery and or surgery) for treatment of up to 5 brain metastases from HER2+ breast cancer


A phase III randomised trial to assess the role of adjuvant chest wall irradiation in 'intermediate risk' operable breast cancer following mastectomy. SUPREMO (Selective Use of Postoperative Radiotherapy after MastectOmy)

EORTC 13.08/TROG 15.02 – ROAM

Radiation versus Observation following surgical resection of Atypical Meningioma: a randomised controlled trial

EORTC 22033-26033/TROG 06.01 (Low Grade Glioma)

Primary chemotherapy with temozolomide vs. radiotherapy in patients with low grade gliomas after stratification for genetic 1p loss: a phase III study

ICR-CTSU/2015/15552/TROG 16.03 – CORE

A randomised trial of Conventional care versus Radioablation (stereotactic body radiotherapy) for Extracranial oligometastases


A randomised phase II trial of adaptive image guided standard or dose escalated radiotherapy in the treatment of transitional cell carcinoma of the bladder

TROG 14.03 – EORTC 1219

A blind randomized multicentre study of accelerated fractionated chemo-radiotherapy with or without the hypoxic cell radiosensitizer nimorazole (Nimoral), using a 15-gene signature for hypoxia in the treatment of squamous cell carcinoma of the head and neck.


A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer.

ALTG 14/002/CT0135/TROG 16.01 – NIVORAD

Randomised phase 2 trial of nivolumab and radiotherapy versus nivolumab alone in advanced non-small cell lung cancer progressing after first line chemotherapy


Randomised phase III trial comparing concurrent chemoradiation and adjuvant chemotherapy with pelvic radiation alone in high risk and advanced stage endometrial carcinoma

MASC 01.07/TROG 08.05 – WBRT

Whole Brain Radiotherapy following local treatment of intracranial metastases of melanoma-A randomised phase III trial

MASC 01.09/TROG 08.09 – RTN2

A randomised trial of post operative radiation therapy following wide excision of neurotropic melanoma of the head and neck


Randomised phase 3 trial of radiation plus androgen deprivation therapy with or without enzalutamide for high risk, clinically localised, prostate cancer
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