Past trials

TROG Cancer Research has 25 closed trials that are awaiting final closeout activities to be completed and 43 published trials closed with all activity completed. 

As of 31 December 2019, 14,715 volunteers had participated in or are currently participating in one of the 96 TROG Cancer Research clinical trials that span across a range of tumour types.

Category Key

ANZMTG 01.02/TROG 02.01

A Randomised Clinical Trial of Surgery Versus Surgery Plus Adjuvant Radiotherapy for Regional Control in Patients With Completely Resected Nodal Metastatic Melanoma


"Phase III Randomized Trial of Concomitant Radiation, Cisplatin, and Tirapazamine (SR259075) Versus Concomitant Radiation and Cisplatin in Patients With Advanced Head and Neck Cancer"

TROG 01.02 – PCNSL

A Phase 2 Study of Idarubicin Based Combined Modality Therapy in Primary Central Nervous System Lymphoma

TROG 01.04 – Rectal (Phase III)

A Randomised Trial of Preoperative Radiotherapy for Stage T3 Adenocarcinoma of the Rectum

TROG 01.05 – Superdex/Spinal Cord Compression

A Pilot Randomised Controlled Trial of Dexamethasone 96mg Versus 16mg Per Day for Malignant Spinal Cord Compression Treated by Radiotherapy - TROG SuperDex Pilot

TROG 02.03 – BLADDER (Phase III)

Randomised phase III trial of radical chemo/radiotherapy vs radiotherapy alone in the definitive management of localised muscle invasive TCC of the urinary bladder

TROG 03.01 – Oesophagus

A randomised phase III study in advanced oesophageal carcinoma to compare dysphagia in patients treated with radiotherapy versus chemo-radiotherapy.

TROG 03.02

A Feasibility Study to Evaluate Adjuvant chemo-radiotherapy for Gastric Cancer

TROG 03.04 – RADAR

A randomised trial investigating the effect on biomedical (PSA) control and survival of different durations of adjuvant androgen deprivation in association with definite radiation treatment for localised carcinoma of the prostate (RADAR)

TROG 03.07 – Non Small Cell Lung Cancer

A Randomised Phase II Study of Two Regimens of Palliative Chemoradiation Therapy in the Management of Locally Advanced Non Small Cell Lung Cancer

TROG 04.01 – Cavilon Breast

A Paired Double Blind Randomised Comparison of Cavilon Durable Barrier Cream (CDBC) to 10% Glycerine (“Sorbolene”) Cream in the Prophylactic Management of Post-Mastectomy Irradiation Skin Care.

TROG 04.02 – Cervical – FIGO Stage & Tumour Volume

Prospective Study to Determine the Relationships Between Survival and FIGO Stage, Tumour Volume and Corpus Invasion in Cervical Cancer.

TROG 05.01 – POST

Post operative concurrent chemo-radiotherapy versus post-operative radiotherapy in high-risk cutaneous squamous cell carcinoma of the head and neck.

TROG 05.02 – MALT Lymphoma

A prospective single arm trial of involved field radiotherapy alone for stage I-II low grade non-gastric marginal zone lymphoma.

TROG 06.02 – APBI

A Multicentre Feasibility Study of Accelerated Partial Breast Irradiation Using Three-Dimensional Conformal Radiation Therapy for Early Breast Cancer

TROG 07.03 – RadioHUM

Radiotherapy with humidification in head and neck cancer. A randomized phase III trial of the Trans Tasman Radiation Oncology Group

TROG 07.04

A Phase I/II trial of Cetuximab, Carboplatin and Radiotherapy for patients with locally advanced Head and Neck Squamous Cell Carcinoma.

TROG 09.01 – PROArCT

A phase II trial of integrated preoperative radiotherapy and chemotherapy with oxaliplatin 5-FU and folinic acid in patients with locally advanced rectal cancer.


A randomised phase III trial of highly conformal hypofractionated image guided (“Stereotactic”) radiotherapy (HypoRT) versus conventionally fractionated radiotherapy (ConRT) for inoperable early stage I non small cell lung cancer.


A multicentre feasibility study of online adaptive image guided radiotherapy for muscle invasive bladder cancer.


A randomised phase III trial of high dose palliative radiotherapy (HDPRT) versus concurrent chemotherapy and HDPRT (C-HDPRT) in patients with good performance status, locally advanced/small volume metastatic NSCLC not suitable for radical chemo-radiotherapy.


The Assessment of New Radiation Oncology Technologies and Treatment


ANROTAT Radiation Oncology Register Pilot


PET scans for locally advanced breast cancer and diagnostic MRI to determine the extent of operation and radiotherapy

TROG 13.01 – SAFRON II/ALTG 13.001

Stereotactic body radiotherapy in lung metastases from any non haematological primary cancer.

TROG 14.04 – HART

Deep Inhalation Breath Hold for reduction of cardiac toxicity in patients with left sided breast cancer undergoing radiotherapy

TROG 15.01 – SPARK

Stereotactic Prostate Adaptive Radiotherapy utilising KIM (Kilovoltage Intrafraction Monitoring) SPARK

TROG 89.02 – Breast CMF & RT

Simultaneous Adjuvant Radiation and CMF Chemotherapy Following Surgery for Breast Cancer

TROG 89.03 – Upper Aero-Digestive Track – Accelerated RT

TROG 89.04 – Oesophageal – Synchronous RT & CT

Synchronous Radiotherapy and Chemotherapy in Oesophageal Cancer

TROG 91.01 – Head & Neck – Accelerated RT

A Phase III Prospective Randomised Clinical Trial of Accelerated Radiotherapy (ART) for Stage III and IV Squamous Carcinoma of the Upper Aerodigestive Tract

TROG 92.01 – PCNSL (Phase II)

A Phase II Study of Intravenous Methotrexate and Cranial Irradiation in the Treatment of Primary Central Nervous System Lymphoma (PCNSL)

TROG 94.01/AGITG IG9401 – Oesophagus – Localised Resectable (IG9401)

A Randomised Phase III Clinical Trial Comparing Surgery Alone with Concurrent Preoperative Chemotherapy and Radiation Followed by Surgery For Localised Resectable Carcinoma of the Oesophagus

TROG 95.01 – Rectal Cancer

A Randomised Trial Comparing Adjuvant Protracted Venous Infusion and Bolus 5FU/Leucovorin with Either Early or Late Radiotherapy in Rectal Caner

TROG 95.02 – Proctitis – Rectal Sucralfate

A Phase III Double-Blind Randomised Trial of Rectal Sucralfate Suspension in the Treatment of Radiation Proctitis

TROG 95.03 – Proctitis PPS

Phase III Double Blind Study of Pentosan Polysulphate Sodium (PPS) in the treatment of Late (Chronic ) Radiation Proctitis

TROG 96.01 – Prostate – Androgen Deprivation

A Randomised Trial Investigating the Effectiveness of Different Durations of Maximal Androgen Deprivation Prior to and During Definitive Radiation Therapy for Locally Advanced Carcinoma of the Prostate

TROG 96.02 – Oesophagus

Standard Radio-Chemotherapy for Oesophageal Cancer Patients

TROG 96.03 – Accelerated Radiotherapy Oesophagus

Concomitant Accelerated Radiotherapy Boost for Good Prognosis Oesophageal Patients

TROG 96.04 – Liver Metastases – Glucocorticoid Steroids

Phase III Comparison of Radiotherapy with Glucocorticoid Steroid Support for the Palliation of Liver Metastases

TROG 96.05 – Neuropathic Bone

A Prospective Randomised Trial of Single Fraction Verses Fractionated Radiotherapy of Neuropathic Pain Due to Bone Metastases

TROG 96.06 – Melanoma (Phase II)

A Phase II Study of Radiation Therapy Following Nodal Surgery in Malignant Melanoma

TROG 96.07 – Merkel Cell – Skin

A Phase II Study of Synchronous Carboplatin/Etoposide And Radiation In Merkel Cell Carcinoma Of The Skin

TROG 97.01 – Bladder (Phase II)

A Phase II Study of Trans-Urethral Resection Followed by Synchronous Chemo-Radiation in the Definitive Management of Localised Invasive TCC of the Urinary Bladder

TROG 98.01 – Rectal (Phase II)

A Phase II Trial Of Preoperative Radiotherapy With Protracted Infusion 5-Fluorouracil For Resectable Adenocarcinoma Of Rectum

TROG 98.02/EFC3344 – Head & Neck/Tirapazamine (Phase II)

Randomised Phase II Study of Two Different Strategies for Chemoradiotherapy in Advanced Squamous Cell Carcinoma of the Head and Neck

TROG 98.03 – Prostate – Margin +ve Post-Prostatectomy

Randomised Trial to Compare the Rates of Disease-Free Survival in Margine-Positive Patients After Radical Prostatectomy With or Without Adjuvant Post-Operative Radiotherapy

TROG 98.04 – Liver Metastases

Phase II Study Examining the Efficacy of Short Fractionation Radiotherapy for the Palliation of Liver Metastases

TROG 98.05 – Solitary Brain Metastases

A Randomised Trial of Immediate Versus Delayed Whole Brain Irradiation Following Surgery and/or Radiosurgery for patients with one or two brain metastases.

TROG 98.06 – Oesophagus

Concurrent Radiotherapy and Chemotherapy for Oesophageal Cancer Patients

TROG 99.02 – Anal Canal

A Prospective Single Arm Non Randomised Study of Concurrent Radiation and Chemotherapy For the Organ Conserving Treatment of Early Anal Canal Cancer

TROG 99.03 – Follicular Lymphoma

A Randomised Multicentre Trial Of Involved Field Radiotherapy Versus Involved Field Radiotherapy Plus Chemotherapy In Combination With Rituximab (Mabthera®) For Stage I – II Low Grade Follicular Lymphoma

TROG 99.04/ALLG LY02 – Osteolymphoma – OL

A Prospective, Non-Randomised Study of Chemotherapy and Radiotherapy for Osteolymphoma (OL)

TROG 99.05 – Lung Tumour Volume

Tumour Volume as an Independent Prognosis Factor in Patients with Non-Small Cell Lung Cancer: A Protocol for a Progressive Database

TROG 99.06 – Bladder (Phase II)

Phase I/II Study of Trans-Urethral Resection Followed by Modified Synchronous Chemo-Radiation in the Definitive Management of Localised Invasive TCC of the Urinary Bladder

AG0307OS/TROG08.07 – DECO

"The DECO Study: A Randomised Phase II Trial of Weekly Docetaxel (Taxotere) Chemoradiotherapy +/- Cetuximab (Erbitux) in the Treatment of Localised Resectable Cancer of the Oesophagus."

ANZLG HD3/TROG 99.01 – Hodgkins Disease IFRT – HD3

An ANZLG / TROG Prospective Study of Limited Chemotherapy and Involved Field Radiotherapy for Patients With Clinical Stage I-II Hodgkin’s Disease

EORTC 22996-24002/TROG 01.01 – EPO Head & Neck

A Phase III Double-Blind, Randomized, Placebo-Controlled Study of Erythropoietin When Used as an Adjuvant to Radiation Therapy in Patients With Head & Neck Squamous Cell Carcinoma

EORTC/TROG 01.03 – Glioblastoma/Temozolomide – 26981/22981

Concomitant and Adjuvant Temozolomide and Radiotherapy for Newly Diagnosed Glioblastoma Multiforme. A Randomized Phase III Study

MA.20/NCIC CTG/TROG 03.05 – MA.20

A Phase III Study of Regional Radiation Therapy in Early Breast Cancer


A Phase III multi-centre randomised controlled trial to assess whether optimal supportive care alone (including Dexamethasone ) is as effective as optimal supportive care (including Dexamethasone) plus whole brain radiotherapy in the treatment of patients with inoperable brain metastases from non-small cell lung cancer.

NCIC CTG CE.6/TROG 08.02 – GBM in Elderly Patients

A Randomised Phase III study of Temozolomide and short-course radiation versus short-course radiation alone in the treatment of newly diagnosed glioblastoma multiforme in elderly patients.


A randomised trial of shorter radiation fractionation schedule for the treatment of localised prostate cancer (Prostate Fractionated Irradiation Trial)

TROG 10.02 – RAPID

Randomized trial of accelerated partial breast irradiation


A randomised phase III study of single fraction radiotherapy compared to multifraction radiotherapy in patients with metastatic spinal cord compression

TROG 17.06 – SC.24

A Phase III Randomized Feasibility Study Comparing Stereotactic Body Radiotherapy (SBRT) Versus Conventional Palliative Radiotherapy (CRT) For Patients With Spinal Metastases


An ALLG/TROG Prospective Multicentre Study of Involved-Field Radiotherapy with Transplantation for Patients with Hodgkin’s Disease and non-Hodgkin’s Lymphoma

TROG 03.06/VCOG PR 01-03 – TOAD

A collaborative randomised phase III trial: The timing of intervention with androgen deprivation in prostate cancer patients with a rising PSA.

UON/TROG 12.03 – EAT

Eating As Treatment (EAT): An RCT of psychological training for dieticians to reduce malnutrition and depression in head and neck cancer patients undergoing radiotherapy.
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