Primary sponsor: The Walton Centre NHS Foundation Trust, University of Liverpool, UK
Collaborating group: European Organisation for Research and Treatment of Cancer (EORTC); Trans Tasman Radiation Oncology Group (TROG)

Title

Radiation versus Observation following surgical resection of Atypical Meningioma: a randomised controlled trial

Summary

This trial aims to determine whether early adjuvant fractionated external beam radiotherapy reduces the risk of tumour recurrence compared to active monitoring in newly diagnosed atypical meningioma.

Atypical meningioma is a tumour that arises from the lining of the brain. It mostly affects adults, with most patients in the 40-60 year age group. The primary treatment for atypical meningioma is surgical removal, but with surgery alone, up to 40% of patients will experience recurrence. Because of this risk, some clinicians give early radiotherapy, whilst others advise regular monitoring with radiotherapy given only at recurrence. Currently, there is no consensus as to which of these two approaches is best. This randomised controlled trial will compare the two approaches, and aims to determine whether early radiotherapy reduces the risk of tumour recurrence compared to regular monitoring in newly diagnosed atypical meningioma.