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Cancer Types

Skin Cancer

The TROG 96.06 trial showed that the risk of skin cancer recurring following lymph node surgery for melanoma could be dramatically reduced with a course of radiation therapy following surgery.

The study was conducted over 11 years involving more than 200 patients recruited from seven cancer centres in Australia and New Zealand. This study showed that the chance of skin cancer reappearing was reduced by approximately 30 per cent with the addition of radiotherapy following the standard surgical treatment. The trial was based on results of the TROG 96.06 study and supported the results in favour of surgery plus radiation therapy. 

Squamous cell carcinoma of the skin is one of the most common cancers affecting Australians. The majority are readily cured with simple local therapy, such as surgery.

, Skin Cancer, TROG Cancer Research

However some patients develop advanced disease requiring surgery and post-operative radiotherapy. Despite this, some patients do not achieve cure. The TROG 05.01 trial aimed to improve cure rates for these patients by comparing post-operative radiotherapy (control arm) to post-operative chemo-radiotherapy (experimental arm).

The results showed that for patients with advanced squamous cell carcinoma of the head and neck, surgery and postoperative radiotherapy resulted in high cure rates, in excess of 85 per cent. This confirmed confirms that surgery and post-operative radiotherapy should be considered the standard of care for treating this disease. The trial also showed that the addition of chemotherapy did not improve cure rates. This practice changing research will save patients from the added side effects associated with chemotherapy

The purpose of the ANZMTG 01/07 TROG 08.05 trial was to investigate the effect of adding whole brain radiotherapy after surgery and/or stereotactic irradiation (SI) on the development of further brain metastases (cancer spread to the brain) in participants with melanoma. The results have shown that whole-brain radiotherapy (WBRT) does not improve intracranial control, survival, or performance after local treatment of one to three melanoma brain metastases.

EORTC 13.08/TROG 15.02 – ROAM

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