Cancer Types

Lymphoma Cancer

The primary aim of the TROG 99.03 trial was to see if, by adding immuno-chemotherapy to the standard treatment of radiotherapy alone, outcomes could be improved for patients with stage I-II low-grade follicular lymphoma. This multi-centre international study, which accrued 150 participants across Australia, New Zealand and Canada, was the first of its kind to be conducted and helped define the standard of care for these patients.

It is clear from the trial results that radiotherapy plus R-CVP (the name of a combination of cancer drugs), is associated with a much better chance that patients will survive to 10 years without a relapse. The results of this trial will inform every discussion of a treatment strategy for every patient with stage I-II follicular lymphoma in the developed world.

The TROG 99.04 trial, which looked at chemotherapy and radiation therapy as a treatment for Osteo Lymphoma (OL), showed a relatively high rate of local and distant disease control, as well as a low rate of toxicity. It remains the only prospective trial addressing this disease and it has provided TROG with valuable experience in the testing of rare diseases.

, Lymphoma Cancer, TROG Cancer Research

ALLG/HDNLHL04/TROG 03.03

An ALLG/TROG Prospective Multicentre Study of Involved-Field Radiotherapy with Transplantation for Patients with Hodgkin’s Disease and non-Hodgkin’s Lymphoma

ANZLG HD3/TROG 99.01 – Hodgkins Disease IFRT – HD3

An ANZLG / TROG Prospective Study of Limited Chemotherapy and Involved Field Radiotherapy for Patients With Clinical Stage I-II Hodgkin’s Disease

ONJCRI RaDD

Phase I dose escalation study of Radiotherapy and Durvalumab (MEDI4736) in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL) & Follicular Lymphoma (FL): The RaDD study

TROG 01.02 – PCNSL

A Phase 2 Study of Idarubicin Based Combined Modality Therapy in Primary Central Nervous System Lymphoma

TROG 05.02 – MALT Lymphoma

A prospective single arm trial of involved field radiotherapy alone for stage I-II low grade non-gastric marginal zone lymphoma.

TROG 92.01 – PCNSL (Phase II)

A Phase II Study of Intravenous Methotrexate and Cranial Irradiation in the Treatment of Primary Central Nervous System Lymphoma (PCNSL)

TROG 99.03 – Follicular Lymphoma

A Randomised Multicentre Trial Of Involved Field Radiotherapy Versus Involved Field Radiotherapy Plus Chemotherapy In Combination With Rituximab (Mabthera®) For Stage I – II Low Grade Follicular Lymphoma

TROG 99.04/ALLG LY02 – Osteolymphoma – OL

A Prospective, Non-Randomised Study of Chemotherapy and Radiotherapy for Osteolymphoma (OL)