Cancer Types

Gastrointestinal Cancer

The TROG 01.04 trial was designed to compare short-course (5 days of radiotherapy) and long- course (5.5 weeks of chemotherapy and radiotherapy) treatments delivered prior to cancer surgery in patients with localised rectal cancer. 326 patients were recruited into the trial. The results showed that at 5 years after treatment, the local recurrence rates were similar between both treatment groups.

The research also showed no differences in the risk of cancer spreading elsewhere in the body or in life expectancy between the two treatments. The trial confirmed that when delivered prior to cancer surgery, both short and long-course treatments are effective in the management of localised rectal cancer. Short-course radiotherapy may be an appropriate option for patients who cannot tolerate chemotherapy, and this treatment is easier to deliver. This allows cancer doctors to tailor personalised treatment decisions for individual patient needs.

, Gastrointestinal Cancer, TROG Cancer Research

The TROG 03.02 trial was launched to test the feasibility of a novel chemoradiation regimen for gastric cancer. The trial found that chemoradiation was feasible and could be safely delivered in a cooperative group setting. The three-year survival rate of 61.6 per cent was encouraging, especially given that many centres were implementing this treatment for the first time.

AG0307OS/TROG08.07 – DECO

"The DECO Study: A Randomised Phase II Trial of Weekly Docetaxel (Taxotere) Chemoradiotherapy +/- Cetuximab (Erbitux) in the Treatment of Localised Resectable Cancer of the Oesophagus."

AGITG AG0407GR/TROG 08.08 – TOPGEAR

A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer.

AGITG TROG 21D RESOLUTE

Randomised Phase II Trial to Evaluate the Strategy of Integrating Local Ablative Therapy with First-Line Systemic Treatment for Unresectable Oligometastatic Colorectal Cancer

AGITG/TROG 18.04 – MASTERPLAN

A Randomised Phase II Study of MFOLFIRINOX And Stereotactic Radiotherapy (SBRT) for Pancreatic Cancer With High Risk and Locally Advanced Disease

E33036 IAEA HCC

RANDOMIZED STUDY OF STEREOTACTIC BODY RADIATION THERAPY (SBRT) VERSUS TRANSARTERIAL CHEMOEMBOLIZATION (TACE) IN HEPATOCELLUAR CARCINOMA

TROG 01.04 – Rectal (Phase III)

A Randomised Trial of Preoperative Radiotherapy for Stage T3 Adenocarcinoma of the Rectum

TROG 03.02

A Feasibility Study to Evaluate Adjuvant chemo-radiotherapy for Gastric Cancer

TROG 09.01 – PROArCT

A phase II trial of integrated preoperative radiotherapy and chemotherapy with oxaliplatin 5-FU and folinic acid in patients with locally advanced rectal cancer.

TROG 89.04 – Oesophageal – Synchronous RT & CT

Synchronous Radiotherapy and Chemotherapy in Oesophageal Cancer

TROG 94.01/AGITG IG9401 – Oesophagus – Localised Resectable (IG9401)

A Randomised Phase III Clinical Trial Comparing Surgery Alone with Concurrent Preoperative Chemotherapy and Radiation Followed by Surgery For Localised Resectable Carcinoma of the Oesophagus

TROG 95.01 – Rectal Cancer

A Randomised Trial Comparing Adjuvant Protracted Venous Infusion and Bolus 5FU/Leucovorin with Either Early or Late Radiotherapy in Rectal Caner

TROG 96.02 – Oesophagus

Standard Radio-Chemotherapy for Oesophageal Cancer Patients

TROG 96.03 – Accelerated Radiotherapy Oesophagus

Concomitant Accelerated Radiotherapy Boost for Good Prognosis Oesophageal Patients

TROG 98.01 – Rectal (Phase II)

A Phase II Trial Of Preoperative Radiotherapy With Protracted Infusion 5-Fluorouracil For Resectable Adenocarcinoma Of Rectum

TROG 98.06 – Oesophagus

Concurrent Radiotherapy and Chemotherapy for Oesophageal Cancer Patients

TROG 99.02 – Anal Canal

A Prospective Single Arm Non Randomised Study of Concurrent Radiation and Chemotherapy For the Organ Conserving Treatment of Early Anal Canal Cancer

USYD/TROG 17.03 – LARK

Liver Ablative Radiotherapy utilizing Kilovoltage intrafraction monitoring