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Cancer Types

Head & Neck Cancer

The TROG 07.03 RadioHum trial evaluated the impact of humidification on mucositis in patients treated for head and neck cancer. Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract, usually as an adverse effect of chemotherapy and radiotherapy treatment for cancer. 

Although it did not demonstrate a significant difference between the mucositis experienced by the two groups, the results show that humidification can play a role in reducing symptoms during radiation therapy for head and neck cancer. On average, patients who received humidification spent less time in the hospital to manage side effects. The return of eating patterns to close to normal was also significantly higher at three months after radiation therapy in the group using humidifiers. The secondary analyses are currently underway. 

, Head & Neck Cancer, TROG Cancer Research


"Phase III Randomized Trial of Concomitant Radiation, Cisplatin, and Tirapazamine (SR259075) Versus Concomitant Radiation and Cisplatin in Patients With Advanced Head and Neck Cancer"


A Situation Analysis of National Radiotherapy Resources and Patterns of Care for Patients with Nasopharyngeal Carcinoma in Low-Middle Income Countries: Can Enhancing the Quality of Radiotherapy Planning Improve Outcomes

EORTC 22996-24002/TROG 01.01 – EPO Head & Neck

A Phase III Double-Blind, Randomized, Placebo-Controlled Study of Erythropoietin When Used as an Adjuvant to Radiation Therapy in Patients With Head & Neck Squamous Cell Carcinoma

MASC 01.07/TROG 08.05 – WBRT

Whole Brain Radiotherapy following local treatment of intracranial metastases of melanoma-A randomised phase III trial

TROG 05.01 – POST

Post operative concurrent chemo-radiotherapy versus post-operative radiotherapy in high-risk cutaneous squamous cell carcinoma of the head and neck.

TROG 07.03 – RadioHUM

Radiotherapy with humidification in head and neck cancer. A randomized phase III trial of the Trans Tasman Radiation Oncology Group

TROG 07.04

A Phase I/II trial of Cetuximab, Carboplatin and Radiotherapy for patients with locally advanced Head and Neck Squamous Cell Carcinoma.


A randomised trial of weekly cetuximab and radiation versus weekly cisplatin and radiation in good prognosis loco regionally advanced HPV-associated oropharyngeal squamous cell carcinoma

TROG 14.03 – EORTC 1219

A blind randomized multicentre study of accelerated fractionated chemo-radiotherapy with or without the hypoxic cell radiosensitizer nimorazole (Nimoral), using a 15-gene signature for hypoxia in the treatment of squamous cell carcinoma of the head and neck.

TROG 91.01 – Head & Neck – Accelerated RT

A Phase III Prospective Randomised Clinical Trial of Accelerated Radiotherapy (ART) for Stage III and IV Squamous Carcinoma of the Upper Aerodigestive Tract

TROG 98.02/EFC3344 – Head & Neck/Tirapazamine (Phase II)

Randomised Phase II Study of Two Different Strategies for Chemoradiotherapy in Advanced Squamous Cell Carcinoma of the Head and Neck

UON/TROG 12.03 – EAT

Eating As Treatment (EAT): An RCT of psychological training for dieticians to reduce malnutrition and depression in head and neck cancer patients undergoing radiotherapy.