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TROG 08.02 (GBM in elderly patients)

Primary sponsor: CCTG (CE.6)
Collaborating groups: TROG


A study of temozolomide and short-course radiation versus short-course radiation alone in the treatment of newly diagnosed glioblastoma multiforme in elderly patients


Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known whether radiation therapy and temozolomide are more effective than radiation therapy alone in treating glioblastoma multiforme (GBM).

This trial is studying radiation therapy and temozolomide to see how well they work compared with radiation therapy alone in treating patients with newly diagnosed GBM.

Final accrual

560 (including 97 Aus/NZ TROG sites)

Closing date

Closed January 2014

Trial chairpersons

Dr Claire Phillips, Peter MacCallum Cancer Centre, VIC
Dr Mike Fay, Royal Brisbane Hospital, QLD

Trial contact

Laura Galletta
Peter MacCallum Cancer Centre

Trial resources for TROG members

TROG 08.02 member page

We are thankful to our 14,500 patients who have participated in our research. Please continue the generous support.