TROG Cancer Research
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TROG 06.01

Primary sponsor: EORTC
Collaborating groups: TROG, CCTG, MRC-NCRI, Brain Tumour Group


Radiation Therapy or Temozolomide in Treating Patients With Gliomas


Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. At the time of writing this protocol it was not known whether radiation therapy was more effective than temozolomide in treating gliomas.

The purpose if this randomized phase III trial was to study radiation therapy to see how well it works compared to temozolomide in treating patients with gliomas.

Final accrual

EORTC: 707 registered / EORTC 473 randomised
TROG: 69 registered / TROG 40 randomised

Trial Status

Closed to accrual, March 2010

Trial chairpersons

Dr Gail Ryan, Peter MacCallum Cancer Centre, VIC

Trial contact

Patrick Wheeler
TROG Trial Coordinating Centre
Phone: +61 2 401 43903

Further information

Trial resources for TROG members

TROG 06.01 member page

We are thankful to our 14,500 patients who have participated in our research. Please continue the generous support.