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Closed Brain and Central Nervous System trials

Trials closed to recruitment

TROG 17.06 (SC.24) - this study aims to find out if SBRT is better than CRT at controlling pain in the spine 3 months after receiving treatment.

Primary sponsor: Canadian Cancer Trials Group 

Collaborating groups: TROG


TROG 15.02 (ROAM) - Radiation versus Observation following surgical resection of Atypical Meningioma: a randomised controlled trial 

Primary sponsor: The Walton Centre NHS Foundation Trust, University of Liverpool UK
Collaboration Groups: EORTC, TROG


TROG 08.05 (WBRT) - this study investigates the effect of adding whole brain radiotherapy after surgery and/or stereotactic irradiation (SI) on the development of further brain metastases (cancer spread to the brain) in participants with melanoma.


Primary sponsor: Australia & New Zealand Melanoma Trials Group (ANZMTG)
Collaborating groups: TROG; Sydney Neurology Oncology Group (SNOG)


TROG 08.02 (GBM in elderly patients) - this trial is studying radiation therapy and temozolomide to see how well they work compared with radiation therapy alone in treating patients with newly diagnosed glioblastoma multiforme.

Primary sponsor: National Cancer Institute of Canada Clinical Trials Group (NCIC CTG)
Collaborating groups: TROG; European Organisation for Research & Treatment of Cancer (EORTC)


TROG 06.01 - drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumour cells. The study aimed to determine whether radiation therapy was more effective than temozolomide in treating gliomas.

Primary sponsor: European Organisation for Research & Treatment of Cancer (EORTC)
Collaborating groups: TROG; National Cancer Institute of Canada (NCIC); Medical Research Council (MRC) - National Cancer Research Institute (NCRI); Brain Tumour Group


Completed trials

TROG 07.02 (Quartz) - Dexamethasone and Supportive Care With or Without Whole-Brain Radiation Therapy in Treating Patients with Non-Small Cell Lung Cancer That Has Spread to the Brain and Cannot Be Removed By Surgery

TROG 01.03 - Concomitant and Adjuvant Temozolomide and Radiotherapy for Newly Diagnosed Glioblastoma Multiforme. A Randomized Phase III Study

TROG 98.05 - A Randomised Trial of Immediate Versus Delayed Whole Brain Irradiation Following Surgery and/or Radiosurgery for patients with one or two brain metastases

We are thankful to our 14,500 patients who have participated in our research. Please continue the generous support.