TOPGEAR trial results published in the New England Journal of Medicine

TOPGEAR trial findings published in NEJM

18 September 2024: We’re thrilled to announce the release of globally significant results from the AGITG TOPGEAR study on which TROG collaborated, providing practice-changing evidence about preoperative chemoradiotherapy for gastric cancer. The findings, announced simultaneously at the European Society for Medical Oncology Congress in Barcelona, Spain and published in

AGITG AG0407GR/TROG 08.08 – TOPGEAR

The aim of this trial is to investigate whether pre-operative treatment with chemotherapy plus radiation therapy has a better outcome than chemotherapy alone in patients undergoing surgery for resectable gastric cancer.

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Make a difference – your way.Donate or fundraise to support our life-saving cancer research.Support TROGTaking part in a Clinical Trial.Discover the benefits for your own care, and the future of cancer treatment for everyone.Learn MoreLeading life-saving cancer research for more than 35 years.Read the latest news about how our

TROG 2024 Annual Research Report highlights a year of achievements

LATEST NEWS: 24 JUNE 2025 The latest annual report from TROG Cancer Research showcases a year of impactful research, global collaboration and initiatives to support equity in radiation therapy clinical trials. Highlights in the 2024 Annual Research Report include: TROG President A/Prof Puma Sundaresan highlighted the organisation’s robust financial

TROG Awards Recognise Research Excellence

Latest news: 28 March 2025. TROG Members who have made significant contributions both to the work of TROG and to advancing radiation medicine clinical trial research more broadly were recognised with our 2025 Research Excellence Awards this month. We congratulate the following winners on their well-deserved awards, which were

Sebastian with children Luke and Luna

Sebastian’s Story

Sebastian’s Story Participant Story Sebastian Mysiorek Melbourne, Victoria Sebastian Mysiorek participated in the AGITG AGO407GR/TROG 08.08 TOPGEAR clinical trial investigating whether adding radiation therapy to chemotherapy prior to surgery is beneficial in gastric cancer.   Sebastian Mysiorek’s new life in Australia was thrown into turmoil when he underwent tests

Mavis’ Story

Mavis’ Story Participant Story Mavis De La Pierre Melbourne, Victoria After being diagnosed with stomach cancer, Mavis De La Pierre, a grandmother from Melbourne, Victoria, participated in the AGITG AGO407GR/TROG 08.08 – TOPGEAR clinical trial, which investigated whether adding radiation therapy to chemotherapy prior to surgery would improve outcomes

Patient Stories

Benefits of participating in a clinical trial What is a clinical trial? Radiation therapy FAQs Helpful links/resources Patient Stories People are at the heart of our mission at TROG Cancer Research Personal cancer patient stories shared by participants in our trials shed light on what being a trial participant