TROG Cancer Research
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Closed Brain and Central Nervous System trials

Trials closed to recruitment

TROG 08.02 (GBM in elderly patients) - this trial is studying radiation therapy and temozolomide to see how well they work compared with radiation therapy alone in treating patients with newly diagnosed glioblastoma multiforme.

Primary sponsor: National Cancer Institute of Canada Clinical Trials Group (NCIC CTG)
Collaborating groups: TROG; European Organisation for Research & Treatment of Cancer (EORTC)


TROG 06.01 - drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumour cells. The study aimed to determine whether radiation therapy was more effective than temozolomide in treating gliomas.

Primary sponsor: European Organisation for Research & Treatment of Cancer (EORTC)
Collaborating groups: TROG; National Cancer Institute of Canada (NCIC); Medical Research Council (MRC) - National Cancer Research Institute (NCRI); Brain Tumour Group


Completed trials

TROG 07.02 (Quartz) - Dexamethasone and Supportive Care With or Without Whole-Brain Radiation Therapy in Treating Patients with Non-Small Cell Lung Cancer That Has Spread to the Brain and Cannot Be Removed By Surgery

TROG 01.03 - Concomitant and Adjuvant Temozolomide and Radiotherapy for Newly Diagnosed Glioblastoma Multiforme. A Randomized Phase III Study

TROG 98.05 - A Randomised Trial of Immediate Versus Delayed Whole Brain Irradiation Following Surgery and/or Radiosurgery for patients with one or two brain metastases

We are thankful to our 14,000 patients who have participated in our research. Please continue the generous support.